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pentobarbital will lessen the level or effect of buprenorphine, extended-acting injection by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. People who transfer to buprenorphine very long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers need to be monitored to guarant